Mechanism of Action of Bile Acid Sequestrants Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool → ↑ Hepatic Bile Acid Synthesis from Cholesterol → ↓ Intrahepatic Cholesterol Pool → ↑ HMG-CoA Reductase Expression → ↑ VLDL Production/Secretion → ↑ LDL Production → ↑ LDL Receptors → ↑ LDL Clearance → ↓ Plasma LDL-C #biliary #acid #sequestration #pathophysiology #pharmacology #bileacid
