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hematology causes differential abnormal anticoagulation apixaban bleeding bruising dabigatran edoxaban hemostasis inhibitor intravascular management models pathway platelet prolonged rivaroxaban treatment
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
#Coagulation #Cascade ... #clot #PT #PTT ... #diagnosis #models ... anticoagulation #anticoagulant ... #Warfarin #Dabigatran
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... Reduction of pro/anticoagulants
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
- Other anticoagulants ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... #Causes #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/NORMAL PTT: • ... inhibitor and lupus anticoagulant ... syndrome • Lupus anticoagulant ... deficiency • Anticoagulants ... deficiency • Anticoagulant
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