10 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... thiazide-sensitive sodium ... thiazide-sensitive sodium ... ratio 0.5%) Differential ... Syndrome #diagnosis #nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Once pseudohypokalemia is ruled out, causes of hypokalemia can be
- Differential ... (low intake) 2. ... #Differential # ... Algorithm #Causes #workup ... #nephrology
Hypokalemia Differential Algorithm
Acidosis
 - RTA
 - Diarrhea
pH Normal 
 1. Decreased Mg 
 2. Intracellular Shift
Hypokalemia Differential ... NephTwitter) #Hypokalemia ... #Differential # ... Diagnosis #Causes #Workup ... #Nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
- Differential ... acidosis (type 1 of 2) ... Bartter's syndrome, Gitelman's ... #differential # ... algorithm #causes #nephrology
Hypernatremia Differential Diagnosis Algorithm - Diabetes Insipidus Workup

Step #1 - Consider the history
Step #2 - Assess
Hypernatremia Differential ... Diabetes Insipidus Workup ... history Step #2 ... Management #Algorithm #Sodium ... #nephrology #insipidus
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
ascending limb Gitelman ... cell epithelial sodium ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Hypernatremia - Differential ... Diagnosis Workup ... renal mechanism 2) ... #Algorithm #nephrology ... #sodium
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup ... and Differential ... heart failure, neurologic ... Neurologic disorders ... #Hypertension #Workup
Hyponatremia - Diagnosis and Treatment
Hyponatremia is usually caused by the inability to excrete water normally.
3 questions to work ... approach to the differential ... 2) Is ADH elevated ... #Hyponatremia #Differential ... #sodium
Primary Polydipsia
Definition: Excessive volitional water intake
Epidemiology:
 • 6-20% of patients with psychiatric disorders - Most commonly
occurs in only 2- ... diabetes insipidus Differential ... intoxication Initial Workup ... Urine Osm, Serum Sodium ... , Urine Sodium