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diagnosis syndrome aflp apml differentiation fatty hepatology leukostasis liver lysis obgyn obstetrics oncology polychondritis pregnancy relapsing rheumatology tls tumor
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... Pregnancy (AFLP) Pathophysiology ... AP, ↑INR, ↑BUN/Cr ... Monitor and Treat Complications ... #pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... , dyspnea, +/- CXR ... - ACS, AKI, acute ... TLS #diagnosis #management ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... myalgias, HoTN, edema ... common • Imaging: CXR ... APML #diagnosis #management ... #hematology #oncology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
common clinical manifestation ... Multiple myeloma Complications ... : • Airway collapse ... vessel aneurysms • Cardiac ... #diagnosis #management
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