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diagnosis hematology hemophagocytic hlh lymphohistiocytosis symptoms activation behcet differential disease hemeonc leukostasis lysis mas polychondritis relapsing sarcoidosis tls treatment tumor
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Syndrome (MAS) ... Systemic lupus erythematosus ... systemic lupus erythematosus ... #Diagnosis #Management ... #Hematology #Rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
WBC >100k, + lab signs ... lethargy, hematuria, cardiac ... with tetany or cardiac ... TLS #diagnosis #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... with excessive macrophage ... Diagnosis: HLH signs ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... thrombosis, VTE) • Cardiac ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... dysregulation: activated macrophages ... neuropathy or cardiac ... Sarcoidosis #Diagnosis #Management ... #Signs #Symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... ischemia • Skin: Erythematous ... nose, tracheal collapse ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... termed MAS-HLH: Macrophage ... Presentation • Common Signs ... #Hematology #HemeOnc
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
• MAGIC syndrome ... Complications: • Airway collapse ... vessel aneurysms • Cardiac ... Polychondritis #rheumatology ... #diagnosis #management
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