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management differential hematology causes criticalcare disorders hemophagocytic hlh lymphohistiocytosis overview pathophysiology rheumatology shock treatment blood chloride clinical hemepath hypochloremia leukemia
Map of proliferative blood disorders. By Ariella Coler-Reilly @ariellastudies #Algorithm #classification #proliferative #blood #disorders #leukemia #hematology #oncology
By Ariella Coler-Reilly ... ariellastudies #Algorithm ... #classification ... hematology #oncology #diagnosis ... #CML #CLL #AML
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... , Hb), Hepatic dysfunction ... Ferritin >1000 ng/ml ... sIL-2R >2400 Ul/ml
Hypochloremia - Differential Diagnosis Algorithm Cause - Decreased Intake: • Low salt in diet • Exclusive D5W
- Differential Diagnosis ... Algorithm Cause ... Hypotension • AMS ... gastrointestinal osmotic gradient ... #Differential #Diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Algorithm Hodgkin ... relapse - Amy ... Lymphoproliferative #Disorders #Classification ... #differential #algorithm
Guide to systemic mastocytosis Criteria for diagnosis: at least 1 major and 1 minor or 3 minor
Minor: • >25% of all ... tryptase level >20 ng/mL ... tryptase > 200 ng/ml ... without organ dysfunction ... hemepath #pathology #algorithm
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... genetic immune dysfunction ... Diagnosis via genetic ... Low or absent NK cell ... Ferritin >500 ng/mL
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... IL-1 and IL-6, leading ... nervous system (CNS) dysfunction ... 5000 to 10,000 ng/mL ... #Syndrome #Diagnosis
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
rapidly progresses: cell ... death -> end-organ dysfunction ... oliguria (< 0.5 mL ... EmmGeezee #Shock #Classification ... #diagnosis #management
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
rapidly progresses: cell ... death -> end-organ dysfunction ... oliguria (< 0.5 mL ... EmmGeezee #Shock #Classification ... #diagnosis #management
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