12 results
diagnosis rheumatology types erythematosus hypersensitivity reactions sle systemic vasculitis differential hypersensitivityreaction immunology table algorithm allergic comparison criteria cryoglobulinemia cryoglobulins definitions
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... , and systemic lupus ... Hypersensitivity #Types #Classification ... #Pathophysiology
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... • Ex: Systemic Lupus ... #Allergic #Reactions ... #Types #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
antigens, leading to complement ... they activate complement ... glomerulonephritis, Systemic lupus ... reactions #types #allergy ... #table #classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic Lupus ... Acute cutaneous lupus ... anticoagulant • Complement ... #EULARACR #Classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... HLA-DR3 genes, complement ... self-antigens, activating complement ... #Systemic #Lupus ... Erythematosus #SLE #Pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
: • Systemic Lupus ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
activates the complement ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Acute cutaneous lupus ... RNP antibodies, Complement
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... (e.g. systemic lupus ... diagnosis #types #classification
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