21 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... With associated pulmonary ... #Vasculitis #differential ... #diagnosis #algorithm
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... rapidly progressive glomerulonephritis ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... Kumfer @AnnKumfer #Pulmonary
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
progressing GN • New pulmonary ... and/or pulmonary ... • Glomerulonephritis ... arthritis, obstructive pulmonary ... against MPO • Complement
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... alveolar hemorrhage + Glomerulonephritis ... ANCA-positive vasculitis ... ANCA-negative vasculitis ... IgA-associated vasculitis
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Purpura - Diagnostic Algorithm ... trauma, infection, vasculitis ... process such as vasculiitis ... commonly renal and pulmonary ... Purpura #Palpable #Algorithm
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
progressing GN • New pulmonary ... MPO > PR3) • Pulmonary ... , pauci-immune glomerulonephritis ... (Glomerulonephritis ... Mononeuropathy, Glomerulonephritis
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... Autoimmune ANCA vasculitis ... renal failure (glomerulonephritis ... palpable purpura 2/2 vasculitis ... progressive (crescentic) glomerulonephritis
Hemoptysis Differential Diagnosis Framework
Cardiovascular: Pulmonary embolism, Heart failure, Vasculitis, Valvular disease, Arteriovenous malformation
Pulmonary - Airway: Bronchitis,
Cardiovascular: Pulmonary ... Heart failure, Vasculitis ... Arteriovenous malformation Pulmonary ... Differential #Diagnosis #algorithm ... #pulmonary
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... • Low serum C4 complement ... • IgA vasculitis ... • Vasculitis ... #rheumatology #vasculitis
Causes of Hemoptysis - Differential Diagnosis Algorithm
Massive Hemoptysis (>I00 mL in 24 hours)
 • Malignancy
 •
Differential Diagnosis Algorithm ... Vasculitis Infection ... Vasculitis • ... Differential #Diagnosis #Algorithm ... #Causes #Pulmonary