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diagnosis management differential treatment betadglucan causes galactomannan latenttb night sweats tb tuberculosis antibiotic aspergillus bacteremia biomarkers comparison failure falsepositives fever
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess - Diagnosis ... Abscess Pathophysiology ... Lung abscess ... Lung Abscess - Clinical ... Prevotella • Fungal
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: ... Double-stranded RNA • Fungi ... Mannan and glucan components ... vasculature via: • Active ... #InfectiousDiseases
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Fever - Pyrogen Pathophysiology ... Lipopolysaccharide components ... stranded RNA • Fungi ... Mannan and glucan components ... vasculature via: • Active
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... affecting the lungs ... infection (NTM) • Fungal ... abscess Primary ... • Progressive lung
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... of many fungi ... admin of mold-active ... Clav (may be + as long
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... affecting the lungs ... infection (NTM) • Fungal ... abscess Primary ... • Progressive lung
Causes of Antibiotic Failure - Differential Diagnosis Framework Diagnosis: • Non-Infectious: Malignant, Autoimmune, Drug-related (NMS, serotonin syndrome,
bacteria: Viral, Fungal ... Source control (abscess ... ocular), Tissue activity ... (daptomycin in lungs
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
• Cell wall component ... of many fungi ... concurrent admin mold-active ... result in + as long ... closely related fungi
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
bacteria, viruses, fungi ... helper T cells and activate ... Complement: Abs activate ... Memory B cells are long-lived ... Humoral #Immunity #pathophysiology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Aspergillosis Pathophysiology ... Sinusitis • Brain abscess ... change in the lungs ... nails, bronchi, lungs ... ) #Mycoses #InfectiousDiseases
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