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diagnosis management differential infections causes treatment activetb betadglucan brain galactomannan latenttb pulmonary tb tuberculosis abscess aids aspergillus bacteremia biomarkers coccidioidomycosis
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Pathophysiology ... Lipopolysaccharide components ... stranded RNA • Fungi ... Mannan and glucan components ... #Fever #Pathophysiology
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
hypothalamus → fever ... PATHOPHYSIOLOGY: ... Double-stranded RNA • Fungi ... Mannan and glucan components ... #InfectiousDiseases
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... decreased with: concurrent ... Clav (may be + as long ... post-2010 almost never
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... ) • Fungi: Aspergillus ... #Infections #Concurrent ... Diagnosis #causes #infectiousdiseases
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... ) • Fungi: Aspergillus ... #Infections #Concurrent ... Diagnosis #causes #infectiousdiseases
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... Pseudomonas FUNGAL ... cough, myalgia • Lung ... Microsporidium #Lung ... differential #diagnosis #infectiousdiseases
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess - Diagnosis ... Abscess Pathophysiology ... : • 80% have fever ... Intervention: - Fevers ... Prevotella • Fungal
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
• Cell wall component ... of many fungi ... Sensitivity ↓ w/concurrent ... result in + as long ... post-2010 almost never
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... Aspergillosis Pathophysiology ... change in the lungs ... nails, bronchi, lungs ... ) #Mycoses #InfectiousDiseases
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... affecting the lungs ... infection (NTM) • Fungal ... • Progressive lung ... Active TB: • Fever
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