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diagnosis cdc parasite infections betadglucan brain causes differential galactomannan ascariasis ascaris aspergillus bacteremia comparison echinococcus falsepositives hookworm intestinal laboratory loaloa
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Polysaccharide cell wall component ... decreased with: concurrent ... Clav (may be + as long ... #Biomarkers #BetaDGlucan
Echinococcus Life Cycle 1) Adult in small intestine eggs 2) Embryonated egg in feces 3) Oncosphere hatches; penetrates intestinal
commonly liver and lung ... #Echinococcus #LifeCycle ... #diagnosis #pathophysiology ... #infectiousdiseases
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: ... Lipopolysaccharide components ... Double-stranded RNA • Fungi ... Mannan and glucan components ... #InfectiousDiseases
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... ) • Fungi: Aspergillus ... #Infections #Concurrent ... Diagnosis #causes #infectiousdiseases
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... ) • Fungi: Aspergillus ... #Infections #Concurrent ... Diagnosis #causes #infectiousdiseases
Intestinal Hookworm Life Cycle 1) Eggs in feces 2) Rhabditiform larva hatches 3) Development to filariform larva in environment 4)
circulation in the lungs ... Hookworm #Intestinal #lifecycle ... #diagnosis #pathophysiology ... #infectiousdiseases
Ascaris lumbricoides - Ascariasis Life Cycle 1) Adults in small intestine 2) Fertilized egg - Unfertilized egg (will
and migrate to lungs ... lumbricoides #Ascariasis #LifeCycle ... #diagnosis #pathophysiology ... #infectiousdiseases
Loiasis - Loa loa Life Cycle 1) Fly (genus Chrysops) takes a meal (L3 larvae enter bite
blood and in the lungs ... Loiasis #Loaloa #LifeCycle ... #diagnosis #pathophysiology ... #infectiousdiseases
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
• Cell wall component ... of many fungi ... Sensitivity ↓ w/concurrent ... result in + as long ... closely related fungi
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Aspergillosis Pathophysiology ... change in the lungs ... nails, bronchi, lungs ... ) #Mycoses #InfectiousDiseases ... #Fungal #Diagnosis
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