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diagnosis aspergillus betadglucan galactomannan infectiousdiseases biomarkers candida candidemia challenges criticalcare falsepositives fluid fungemia ia laboratory mycoses perioperative preop preoperative responsiveness
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
Diagnosis and Management ... Most invasive infections ... complex Classic Risk ... Diagnosis and Testing ... #treatment #fungal
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Polysaccharide cell wall component ... specificity for invasive ... fungal infection ... useful in high risk ... Galactomannan #diagnosis #comparison
Invasive Fungal Infection (IFI) Invasive fungal infections are severe infections in which fungal pathogens invade normally sterile
Invasive Fungal ... Invasive fungal ... Risk Factors ... Antigen/antibody testing ... when feasible Management
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Evaluation Major ... Key Components: ... Skin exam for infection ... event, follow ACC algorithm ... medical and surgical management
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Galactomannan Testing ... • Cell wall component ... surfaces, Albumin, Infections ... useful in high risk ... colonization vs invasive
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
MUCORMYCOSIS • Risk ... Urinary antigen testing ... Ampho resistant) Invasive ... of 30% to 40% Invasive ... #Diagnosis #Management
Fluid Responsiveness and Fluid Tolerance Testing - OnePager Summary Fluid resuscitation can be beneficial when required or
vasopressors and lower risk ... via cold saline injection ... Minimally Invasive ... #criticalcare #comparison ... #challenges #management
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