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differential hepatology causes rheumatology systemic workup ascites autoantibodies bilirubinemia cholangitis cirrhosis dermatology dili druginduced genitals hepatomegaly igg4 injury jaundice liver
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Systemic Sclerosis ... Digital ulcers, Primary ... Biliary Cirrhosis ... Autoantibodies #diagnosis ... #rheumatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
- Differential Diagnosis ... Algorithm Malignant ... Sclerosing Cholangitis ... • Primary Biliary ... #Hepatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... Hepatic: PBC (primary ... biliary cholangitis ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Genital Skin Ulcers - Differential Diagnosis Algorithm Painful: • Herpes simplex • Haemophilus ducreyi (chancroid) • Behcet's
Genital Skin Ulcers ... - Differential Diagnosis ... Algorithm Painful ... vulgaris • Lichen sclerosis ... Painless: • Primary
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
- Differential Diagnosis ... Algorithm Pre-Hepatic ... Cholangiocarcinoma • Primary ... Sclerosing Cholangitis ... #Algorithm #Causes
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... Algorithm DILI ... toxic aetiology: Skin ... , Primary sclerosing ... #Algorithm #hepatology
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
- Differential Diagnosis ... Algorithm Portal ... biliary cholangitis ... • Primary sclerosing ... #Algorithm #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... Examination: • Skin ... sclerosis group ... #Biliary #Cirrhosis ... #workup #hepatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, particularly scleritis ... arthralgia, arm/leg ... with GCA or as primary ... Rash, arthritis Primary ... #Rheumatology
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
Immune basis: Th2 & Treg ... " pancreas • Biliary ... Tract: IgG4-Sclerosing ... prostate, breast, skin ... DIAGNOSIS
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