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diagnosis rheumatology differential dermatology management algorithm causes erythematosus generalized hepatology lupus pruritus secondary sle syndrome thromboelastogram thromboelastography vasculitis workup ana
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... sclerosis (LcSSc ... sclerosis (DcSSc ... Hepatic: PBC (primary ... #SSc #rheumatology
REBEL Review 54: Thromboelastogram (TEG) Interpretation R Time - Time to start forming clot K Time -
Thromboelastogram (TEG ... ) Interpretation ... amplitude of the TEG ... #hematology #interpretation ... #diagnosis #components
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Systemic Sclerosis ... Digital ulcers, Primary ... BCM_InternalMed #Systemic ... #Sclerosis #Autoantibodies ... #diagnosis #rheumatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Diagnosis Algorithm - Systemic ... == Primary Skin ... • Xerosis (dry skin ... Skin Lesion / Systemic ... #generalized #dermatology
Genital Skin Ulcers - Differential Diagnosis Algorithm Painful: • Herpes simplex • Haemophilus ducreyi (chancroid) • Behcet's
Genital Skin Ulcers ... vulgaris • Lichen sclerosis ... Painless: • Primary ... ulcerative #skinrash #dermatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
sclerosis/scleroderma ... sclerosis/scleroderma ... sclerosis/scleroderma ... Autoimmune Hepatitis, Primary ... ANA #patterns #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Monoclonal Protein/M Component ... Alpha & Mu) Skin ... DADS-M • POEMS (Sclerotic ... myeloma↑VEGF+M component ... Paraproteinemias #Hematology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Associated with skin ... • MCTD (SLE/systemic ... sclerosis/polymyositis ... Summary #diagnosis #rheumatology
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
central nervous system ... Radiographic findings (eg ... Laboratory findings (eg ... VEP’s: EEG of visual ... Progressive MS • Primary
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, particularly scleritis ... arthralgia, arm/leg ... with GCA or as primary ... Rash, arthritis Primary ... Differential #Diagnosis #Rheumatology
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