25 results
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
Bisphosphonate suppresses bone ... damage weakens the bone ... Femur #Fractures #msk ... orthopedics #diagnosis #differential ... #causes #pathophysiology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders - Differential ... Amy Chung, MD, MSc ... Classification #pathophysiology ... #Hematology #Diagnosis ... #NonHodgkin #differential
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... infiltration) Differential ... Liver #Pregnancy #hepatology ... obgyn #diagnosis #management ... #pathophysiology
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Knee Effusions - Differential ... Effusions: - Hematologic ... - Aneurysmal bone ... Osteochondroma Hematologic ... #diagnosis #msk
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
• Ligament • Bone ... the subchondral bone ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup #differential
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... , Biological + Bone ... /ml, ↑ LDH • Bone ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Monoclonal Protein/M Component ... Splenic Marginal Zone ... myeloma↑VEGF+M component ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... check at least one ... Better call hematology ... #Polycythemia #Differential ... Algorithm #workup #hematology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
peripheral nerve components ... surgery, trauma, and bone-marrow ... tested earlier than one ... the underlying pathophysiology ... Syndrome #diagnosis #management
Preoperative Risk Evaluation

Major Pre-Op Questions:
1. Does the patient have any modifiable risk factors that could be
Key Components: ... specific questions to ask ... physical exam - Key components ... HgbA1c - if not done ... medical and surgical management