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differential hypernatremia management syndrome chloride 1 2 3 alkalosis defects di epithelial hypochloremia hypokalemia hyponatremia hypotonic inherited insipidus kidney metabolic
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... thiazide-sensitive sodium-chloride ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypernatremia Differential Diagnosis Algorithm - Diabetes Insipidus Workup Step #1 - Consider the history Step #2 - Assess
Hypernatremia Differential Diagnosis ... Algorithm - Diabetes ... Insipidus Workup ... Hypernatremia #Management #Algorithm ... #Sodium #nephrology
Hypernatremia Diagnosis and Workup Step 1 . Repeat the sodium concentration. Step 2. Check plasma osmolality. NORMAL PLASMA
Hypernatremia Diagnosis ... and Workup Step ... Repeat the sodium ... #Workup #Algorithm ... #Nephrology
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
ascending limb Gitelman ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential ... #Table
Hypochloremia - Differential Diagnosis Algorithm Cause - Decreased Intake: • Low salt in diet • Exclusive D5W
Algorithm Cause ... - Bartter - Gitelman ... Cl⁻ with other components ... #Algorithm #Pathophysiology ... #Nephrology #Chloride
Hypernatremia - Differential Diagnosis Workup Algorithm 1) Check Urine Osmolality: > 600 mOsm/kg - Implies extrarenal mechanism
- Differential Diagnosis ... Workup Algorithm ... #Differential #Diagnosis ... #Workup #Algorithm ... #nephrology #sodium
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
thiazide-sensitive sodium ... thiazide-sensitive sodium ... #Syndrome #diagnosis ... #nephrology #management ... #pathophysiology
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... : SIADH, Renal Sodium ... #differential #diagnosis ... #table #sodium ... #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Urinary Chloride Algorithm ... Bartter syndrome, Gitelman ... the excretion of sodium ... #nephrology #differential ... #diagnosis
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Syndrome (SPS) - Diagnosis ... Person Syndrome Pathophysiology ... antibody that works ... others (botox, sodium ... Management #treatment #neurology
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