16 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... thiazide-sensitive sodium-chloride ... delivery to distal nephron ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... #Localization #Nephron ... #Defects #Pathophysiology ... #Nephrology
Algorithm for Differentiating Gitelman syndrome from Bartter syndrome
 • Urine Chloride
 • Urine Ca/Cr ratio

Dr. Krithika
Differentiating Gitelman ... syndrome • Urine Chloride ... krithicism #Gitelman ... Bartter #Algorithm #nephrology ... #hypokalemia #diagnosis
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
- Differential Diagnosis ... - Bartter - Gitelman ... Cl⁻ with other components ... #Algorithm #Pathophysiology ... #Nephrology #Chloride
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
on the Kidney - Pathophysiology ... loop and distal component ... of Nephron: CHF ... absorption in distal nephron ... KidneyDisease #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Alkalosis - Urinary Chloride ... Bartter syndrome, Gitelman ... Urine chloride is ... urine #Algorithm #nephrology ... #differential #diagnosis
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
thiazide-sensitive sodium chloride ... • Congenital chloride ... #Syndrome #diagnosis ... #nephrology #management ... #pathophysiology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
: Differential Diagnosis ... contracted: urine chloride ... furosemide-like lesion) • Gitelman ... #Differential #Diagnosis ... #Causes #nephrology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Generalized distal nephron ... loads (ammonium chloride ... #differential #diagnosis ... #causes #nephrology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
and lower motor neuron ... Injury #Syndromes #diagnosis ... #pathophysiology ... #orthopedics #neurology