11 results
Recurrent / Breakthrough DVT During Anticoagulation

Subtherapeutic Anticoagulation
Hypercoagulable State 
 - Antithrombin deficiency 
 - Hypercoagulability ot
/ Breakthrough DVT ... Structural - Pelvic masses ... Breakthrough #Recurrent #DVT ... #hematology #differential ... #algorithm
Causes of Breakthrough/Extension of Thrombosis and Management Algorithm

#Anticoagulation #Breakthrough #Thrombosis #Algorithm #Extension #VTE #DVT #Hematology #Management
Causes of Breakthrough ... and Management Algorithm ... #Anticoagulation ... Extension #VTE #DVT ... #Hematology #Management
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Intestine - Other causes ... - Drugs - Primary ... Differential #Diagnosis #Algorithm ... #hepatology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
RPGN has three primary ... pathophysiologic ... causes differentiated ... differential #diagnosis #algorithm ... #rheumatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... intralobular bile ducts causes ... obstruction • ALP ... diagnosis #workup #hepatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... • Elevation of urinary ... Hyophosphatasia #hepatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... assessment+++ Primary ... Griscelli, Purtilo (XLP ... Drugs, Unknown cause ... treatment #summary #rheumatology
Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... Pancytopenia is a hematologic ... a decrease in all ... Leukopenia is primarily ... These causes could
Essential Thrombocythemia (ET)
ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... MI, stroke, DVT/ ... generally requires all ... • Treatment algorithms ... Hydroxyurea + anticoagulation
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... Treat underlying cause ... Lower-extremity weakness, urinary ... stenting - Consider anticoagulation ... AML (~20 %) and APL