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diagnosis differential disorders hematology generalized hypopigmentation oncology pruritus secondary systemic alopecia focal gap globulin hairloss mds monoclonal myelodysplasia myelodysplastic paraproteinemias
Disorders of Pigmentations - Hypopigmentation and Hyperpigmentation - Differential Diagnosis Algorithm HYPOPIGMENTATION Diffuse Congenital - Generalized hypopigmentation of
of hair, eyes, skin ... McCune Albright syndrome ... #disorders #skin ... #dermatology #Differential ... #causes
Skin Hypopigmentation - Differential Diagnosis Algorithm Diffuse Congenital - Generalized hypopigmentation of hair, eyes, skin • Phenylketonuria
Skin Hypopigmentation ... Diffuse Congenital ... • Piebaldism Diffuse ... #dermatology #Differential ... #causes
Skin Hyperpigmentation - Differential Diagnosis Algorithm Diffuse: • Tanning • Adverse cutaneous drug eruption • Addison's disease
Skin Hyperpigmentation ... Diffuse: • Tanning ... McCune Albright syndrome ... #dermatology #Differential ... #causes
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Systemic and Primary Causes ... renal failure/uremia ... Myelodisplastic syndrome ... #generalized #dermatology ... #causes
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Monoclonal Protein/M Component ... Alpha & Mu) Skin ... hypertrichosis, hyperpigmentation ... myeloma↑VEGF+M component ... (-) hemolytic anemia
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
Differential Diagnosis Algorithm ... • Loose anagen syndrome ... - Secondary to Skin ... HairLoss #Alopecia #dermatology ... #causes
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... just beneath the skin ... Workup: • Complete ... #diagnosis #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... renal failure/uremia ... Myelodisplastic syndrome ... #generalized #dermatology ... #causes
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Causes of Monoclonal ... gammopathy, and skin ... changes (POEMS syndrome ... Thalassemia, Sickle cell anemia
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