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diagnosis management cardiology differential mri algorithm b12 c5c9deficiency cardiomyopathy cobalamin complement crypto cryptococcal heartfailure hfref immunology infections infectiousdiseases iron leigh
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Fatigue and IBD ... despite clinical ... UC Anemia and IBD ... IDA and active IBD ... /other causes •
Iron Deficiency in Heart Failure Pathophysiology: Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Iron Deficiency ... → Inflammation causes ... ng/mL (absolute ID ... 20% (functional ID ... #CHF #HFrEF #heartfailure
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
infections • Clinical ... • Bacteria cross ... the blood-brain ... tissue -> Fatigue ... Inflammation of CSF
Leigh Syndrome History: 19-month-old girl with hypotonia, developmental delay, failure to thrive, and bilateral optic disc
History: 19-month-old ... was a complex I deficiency ... Leigh #Syndrome #Clinical ... #MRI #Brain #Diagnosis ... #Radiology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
B12 (Cobalamin) Deficiency ... • Common Causes ... intrinsic factor, IF) Clinical ... slowing, neuropathy, fatigue ... diarrhea related to IBD
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... than 2/3 of the cross-sectional ... • Infectious causes ... ruled out • Brain ... • Nutritional Deficiency
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
exclude other causes ... Clinical • Under-recognized ... May have typical HF ... Avoid ARBs • ICD ... support for patients clinically
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
• Domestic and wild ... status NTM Cause ... massiliense in CF ... • Cross reacts ... 35 percent) • Fatigue
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
headache, high csf ... Nausea & vomiting ... )but severe K+ deficiency ... meningitis #T2 #MRI #Brain ... #clinical #radiology
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