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C. Difficile Infection in IBD - IBD Algorithm

Background
Complications
CDI Testing Algorithm
CDI Recurrence

Dr. Wade Billings @wabillin

#Clostridioides #difficile #CDiff
Difficile Infection ... Complications CDI ... Testing Algorithm CDI ... @wabillin #Clostridioides ... Algorithm #Management #Treatment
Guidelines on Management of Clostridioides difficile Infection (CDI) in Adults
 • Non-Severe CDI
 • Severe CDI
Management of Clostridioides ... difficile Infection ... #Clostridium #Clostridioides ... #management #pharmacology ... #treatment
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook

Clinical Presentation + Progression:
C.diff - Clostridioides ... Difficile Infection ... Perforation) Pathophysiology ... #1 nosocomial infection ... #Cdiff #Clostridioides
IDSA Recommendations for Preventing and Treating Penicillium marneffei Infections in HIV-AIDS
Preventing 1st Episode of Penicilliosis (Primary
Penicillium marneffei Infections ... Treating Acute Infection ... IDSA #Prevention #Treatment ... opportunistic #infections ... #HIVAIDS #pharmacology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Artifact (redo CBC ... Myelofibrosis Infectious ... effect following treatment ... Thrombocytosis #Differential
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
CNS Infection in ... HIV / AIDS - Differential ... Opportunistic Infections ... Antimicrobial treatment ... #differential #
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Triggering factor (infection ... →Activation of CD8 ... Unknown cause Treatment ... diagnosis #management #treatment
IDSA Recommendations for Treating Isospora belli Infection in HIV-AIDS
Treating Isospora belli Infection
General Management Considerations:
 • Fluid
Isospora belli Infection ... Patients with CD4 ... Sustained increase in CD4 ... IDSA #Prevention #Treatment ... #HIVAIDS #pharmacology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Neutrophil (Normal) Differential ... overlook severe infections ... #Bandemia #differential ... neutrophil #WBC #CBC ... #hematology #pathophysiology
IDSA Recommendations for Preventing and Treating Bacterial Enteric Infections in HIV-AIDS
Preventing Bacterial Enteric Illness:
 • Antimicrobial
Bacterial Enteric Infections ... (CDI): • Vancomycin ... IDSA #Prevention #Treatment ... opportunistic #infections ... #HIVAIDS #pharmacology