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IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis - Induction, Consolidation and Maintenance Therapy

Table 2. Antifungal Treatment Recommendations
for Cryptococcal ... Recommendations for Cryptococcal ... Recommendations for Cryptococcal ... #Treatment #management ... #meningitis #cryptococcus
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Human Immunodeficiency Virus Infected Individuals
Induction therapy:
 • AmBd (0.7–1.0
IDSA Treatment Recommendations ... for Cryptococcal ... week) >1 year #Cryptococcal ... #Treatment #management ... #meningitis #cryptococcus
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Transplant Recipients
Induction therapy:
 • liposomal AmB (3–4 mg/kg per
IDSA Treatment Recommendations ... for Cryptococcal ... year B-III #Cryptococcal ... #Treatment #management ... #meningitis #cryptococcus
Differential Diagnosis for Concurrent Brain and Lung Infections
 • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
Diagnosis for Concurrent ... Brain and Lung ... Mucormycosis, Cryptococcus ... @ID_fellows #Brain ... Lung #Infections #Concurrent
Concurrent Brain and Lung Lesions
 • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... Lung #Infections #Concurrent
Concurrent Brain and Lung Lesions
 • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... Lung #Infections #Concurrent
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
fluconazole; ISA ... Aspergillus fumigatus, Cryptococcus ... #antibiogram #management
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
Fluconazole CRYPTOCOCCUS ... level, presence of cryptococcal ... CSF and serum Cryptococcal ... • Sinusitis • Brain ... Fungal #Diagnosis #Management
IDSA Recommendations for Preventing and Treating Cryptococcosis in HIV-AIDS
Treatment for cryptococcosis consists of 3 phases: induction,
IDSA Recommendations ... Cryptococcosis #Cryptococcus ... #IDSA #Prevention ... #Treatment #management