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diagnosis causes differential infections concurrent fungal infectiousdiseases comparison aspergillus atlas betadglucan biomarkers candidemia clinical cns fungemia galactomannan key lesions management
Common Fungal Pathology • Candida - Small yeast intermingled with pseudohyphae • Aspergillosis - Septate
Pathology • Candida ... broad based bud • Cryptococcus ... Pathology #clinical #microscopy
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
lesions • 80% with lung ... histoplasmosis, cryptococcus ... RingEnhancing #Lesions #Brain
Differential Diagnosis for Concurrent Brain and Lung Infections • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
for Concurrent Brain ... and Lung Infections ... Mucormycosis, Cryptococcus ... @ID_fellows #Brain ... #Lung #Infections
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... #Lung #Infections
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... and Lung Lesions ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... #Lung #Infections
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
• Pathogens: Candida ... - Negative: Cryptococcus ... Paecilomyces, Cryptococcus ... Clav (may be + as long
Invasive Fungal Infection (IFI) Invasive fungal infections are severe infections in which fungal pathogens invade normally sterile
Common Pathogens Candida ... pulmonary infections) Cryptococcus ... Diagnosis Culture and microscopy ... galactomannan, cryptococcal ... mortality #candida
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Fluconazole CRYPTOCOCCUS ... level, presence of cryptococcal ... CSF and serum Cryptococcal ... • Sinusitis • Brain ... change in the lungs
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