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IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis - Induction, Consolidation and Maintenance Therapy

Table 2. Antifungal Treatment Recommendations
for Cryptococcal ... Recommendations for Cryptococcal ... Recommendations for Cryptococcal ... Recommendations for Cryptococcal ... management #meningitis #cryptococcus
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
antibiotics once stable ... shows a small, stable ... Dermatitidis - Cryptococcus ... Abscess Differential ... Abscess #pulmonary #differential
Pulmonary Infections in HIV-AIDS
Bacterial: 
 • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
(Histoplasma, Cryptococcus ... failure, COPD, Lung ... ABG, BDG, Serum Cryptococcal ... diagnosis #evaluation #differential
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
lesions • 80% with lung ... histoplasmosis, cryptococcus ... Lesions #Brain #differential
Hematuria in Post-Renal Transplant Patient
Prevalence up to 12% in the postrenal transplant patient
 • Bacterial: Escherichia
Fungal: Candida, Cryptococcus ... Renal #Transplant #differential ... urine #management #treatment
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
Lung Infections ... in HIV - Differential ... pneumonia (PJP), MAI, Cryptococcal ... nodules, plaques) Cryptococcus ... AIDS #pulmonary #differential
Radiographic appearances of pulmonary diseases in HIV/AIDS Patients
 • Diffuse Interstitial Infiltrates: Pneumocystis jirovecii, M.tuberculosis, Histoplasma
Coccidioides spp., Cryptococcus ... Actinomyces spp., NHL; Lung ... pulmonary #diseases #differential
Differential Diagnosis for Concurrent Brain and Lung Infections
 • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
Differential Diagnosis ... Concurrent Brain and Lung ... Mucormycosis, Cryptococcus ... ID_fellows #Brain #Lung ... Infections #Concurrent #Differential
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
- Negative: Cryptococcus ... Paecilomyces, Cryptococcus ... BAL GM does not differentiate ... Clav (may be + as long
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
Fluconazole CRYPTOCOCCUS ... level, presence of cryptococcal ... CSF and serum Cryptococcal ... change in the lungs ... nails, bronchi, lungs