20 results
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
Leukemia) • GI diseases ... liver or kidney disease ... smoking, etoh, decr activity ... #Osteoporosis #pathophysiology ... #signs #symptoms
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... Pathophsiology ... ß-glucocerebrosidase activity ... #Gauchers #Disease ... #Diagnosis #Signs
Brudzinski’s Sign in Meningitis (first described in 19th century by Dr. Josef Brudzinski)

Brudzinski's sign is characterized
Brudzinski’s Sign ... Brudzinski's sign ... While the pathophysiology ... not useful in certain ... despite severe disease
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Pott's Disease in ... cases Clinical Signs ... years - May have signs ... /symptoms of active ... decreased reflexes Pathophysiology
Erythema Annulare Centrifugum (EAC),
This is erythema annulare centrifugum (EAC), one of the “figurate erythemas.” These lesions
lags behind the active ... drugs, systemic disease ... clinical #photo #dermatology ... #skinrash
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Droplets that contain ... Chronic kidney disease ... Progressive lung disease ... Disease: Hematogenous
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Droplets that contain ... Chronic kidney disease ... Progressive lung disease ... Disease: Hematogenous
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
noninflammatory Signs ... Rheumatologic Disease ... whippleii (Whipple's disease ... burgdorferi (Lyme disease ... Diagnosis #MSK #rheumatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... failure PBC Signs ... but elevated as disease ... , IgG4 related disease ... diagnosis #workup #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... IgG > 2x ULN - Certain ... azathioprine (check TPMT activity ... Diagnosis #Management #Hepatology