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Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin ... of anemia include ... • hemolytic anemia ... sensitize red blood cells ... #hematology #diagnosis
Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
 • Myocardium:
	- Heart failure
	- CAD/ACS
	- Valvulopathy
 • Electrical:
	-
- Tamponade Pulmonary ... - Asthma - COPD ... Transverse myelitis • Hematology ... : - Anemia • ... diagnosis #causes #pulmonary
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... deficiency - Syrinx ... Lower motor neuron symptoms ... Upper motor neuron symptoms ... differential #diagnosis #neurology
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
meninges in spinal cord ... nerve roots Spinal Cord ... lymphadenopathy, pulmonary ... Children with pulmonary ... differential #TB #neurology
Pulmonary Hypertension Groups - WHO Classification
Group I - Vascular remodeling of pulmonary arteries
 • Idiopathic, HIV,
Pulmonary Hypertension ... hypoxemia • COPD ... chronic hemolytic anemia ... disorders, sickle cell anemia ... Symptoms of right
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle cells ... Agglutination - Cold ... ARUPLabs #Hemolytic #Anemia ... Algorithm #workup #hematology
Tachypnea - Differential Diagnosis Framework

Definitions
 • Tachypnea: Respiratory rate > 20/min, shallow breathing in adults
 •
deep breathing Pulmonary ... • Asthma • COPD ... Tachypnea: • Pulmonary ... effusion/Tamponade Hematologic ... Tachypnea: • Anemia
Extrapulmonary manifestations of COVID-19
 • Neurologic: Headaches, Dizziness, Encephalopathy, Guillain-Barré, Ageusia, Myalgia, Anosmia, Stroke
 • Renal:
of COVID-19 • Neurologic ... Ageusia, Myalgia, Anosmia ... vein thrombosis, Pulmonary ... ischemia, Acute cor ... Diagnosis #Signs #Symptoms
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
of the spinal cord ... to the spinal cord ... at the spinal cord ... Bilateral signs and/or symptoms ... diagnosis #management #neurology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryofibrinogen is a cold ... - Albumin - Cold ... Cryofibrinogenemia Symptoms ... may include: • Cold ... thrombophlebitis, pulmonary