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diagnosis differential management anemia cold hemolytic agglutinin algorithm als amyotrophic behcet comparison cryofibrinogenemia lateral manifestations monoclonal myelitis neurological oncology paraproteinemias
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin ... of Cold Sensitive ... Cold Agglutinins ... sensitize red blood cells ... hemolytic #anemia #hematology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
Cold Urticaria Prevalence ... skin contact with cold ... minutes after the cold ... 10.1111/all.14674 #Cold ... Urticaria #diagnosis #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogen is a cold ... - Albumin - Cold ... may include: • Cold ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Neurological Manifestations of Tuberculosis Spinal Arachnoiditis & Polyradiculopathy: • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
meninges in spinal cord ... nerve roots Spinal Cord ... lesion Pott's Disease ... lymphadenopathy, pulmonary ... Children with pulmonary
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle cells ... Agglutination - Cold ... agglutinins disease ... , Hemoglobin H disease ... Algorithm #workup #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
of the spinal cord ... to the spinal cord ... at the spinal cord ... Bilateral signs and/or symptoms ... diagnosis #management #neurology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
skin injury) • Neurologic ... matter, spinal cord ... meningitis), MCC CNS symptoms ... management #signs #symptoms ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... affects the skin, neurologic ... • Progressive symptoms ... cognitive impairment, neurologic ... Differential #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... anemia due to cold ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Presentation: - Disease ... multiple spinal cord ... course of the disease ... fasciculations Common Symptoms ... Lateral #Sclerosis #neurology
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