15 results
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
- Spinal Cord Syndromes ... result in permanent neurologic ... deficiency - Syrinx ... Lower motor neuron symptoms ... Upper motor neuron symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Loss of parental copy ... Signs/Symptoms ... , sleep apnea, cor ... pulmonale #PraderWilli ... #Syndrome #genetics
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin ... Cold Agglutinins ... Agglutinin Syndrome ... sensitize red blood cells ... hemolytic #anemia #hematology
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
Hyperviscosity Syndrome ... of breath • Neurologic ... neutrophil count < 500 cells ... Epidural Spinal Cord ... : Tumor Lysis Syndrome
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
meninges in spinal cord ... nerve roots Spinal Cord ... Reconstitution Inflammatory Syndrome ... lymphadenopathy, pulmonary ... Children with pulmonary
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryofibrinogen is a cold ... - Albumin - Cold ... Cryofibrinogenemia Symptoms ... may include: • Cold ... Antiphospholipid syndrome
Cauda Equina Syndrome Overview

Cauda Equina Syndrome:
 • Prevalence: 1:33,000-100,000 ppl/yr
 • Incidence: 1.5-3.4 million ppl/yr
 •
spine L1-L5 Symptoms ... ‘red flag’ symptoms ... Diagnosis: • Spinal cord ... spondylitis • Tethered cord ... diagnosis #causes #neurology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... : - Genetic lesions ... • Improve the symptoms ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
disorder (Cardiac, pulmonary ... • Acute stroke syndromes ... of the spinal cord ... Malignancy-associated myositis • Genetic ... Differential #Diagnosis #neurology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
skin injury) • Neurologic ... matter, spinal cord ... meningitis), MCC CNS symptoms ... management #signs #symptoms ... #rheumatology #