3234 results
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Fever vs Hyperthermia ... Fever: • Regulated ... Endotoxins, Toxins, Cytokines ... rapidly fatal • Causes ... BrighamChiefs #Fever
Pathogenesis of Rheumatic Fever

Pathogenesis of rheumatic fever. 
1. GAS pharyngitis leads to antigenic presentation of pathogenic
Pathogenesis of Rheumatic Fever ... Pathogenesis of rheumatic fever ... infiltration leading to cytokine-mediated ... antibodies which can cause ... #Rheumatic #Fever
Causes of Fever: IMADE Mnemonic
INFECTION
 • Infection 1.0 - Common & Localizing: Base Rate
 • Infection
Causes of Fever: ... carcinomas present with fever ... increased inflammtory cytockines ... with DVT/PE + fever ... IMADE #Mnemonic #Causes
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Allergen-specific lgE causes ... Anaphylaxis, Hay fever ... release inflammatory cytokines
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
pro-inflammatory cytokines ... • Clinical: fever ... Drugs, Unknown cause ... 100 mg/m2) : in case ... emergency, ICU in case
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Epithelioid cells → cytokines ... symptoms are not caused ... General: fever, ... syndrome: ACUTE, fever ... presentation with fever
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
accumulated inflammatory cytokines ... S/sx: Fever, flank ... have drop in Hct, fever ... Causes purpura & ... Sx include: fever
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
accumulated inflammatory cytokines ... S/sx: Fever, flank ... Causes purpura & ... TRALI): Leading cause ... Sx include: fever
Faget Sign - Pulse-Temperature Dissociation
Causes of Relative Bradycardia
 • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Dissociation Causes ... • Infectious Causes ... , Typhoid fever, ... Non-Infectious Causes ... differential #diagnosis #causes
Faget's Sign & Liebermeister's Rule
Pulse-Temperature Dissociation
EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM
INFECTIOUS
BPM INFECTIOUS CAUSES ... • Typhoid Fever ... OTHER CAUSES ... There are specific cases ... #differential #causes