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diagnosis differential clinical hepatology management algorithm pocus ultrasound causes pathophysiology radiology hematology hepatic treatment photo cirrhosis comparison gastroenterology nejm abscess
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... Injury (DILI) ... DILI Types: ... or symptoms of liver ... Drug #induced #Liver
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... and Type of Liver ... Pharmacology #Causes #DILI
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 Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Injury (DILI) - ... Diagnosis Algorithm DILI ... injury, Previous DILI ... hepatitis #DILI
Drug-Induced Liver Injury - Pathophysiology Indirect Idiosyncratic Direct BWH Medicine Chiefs @BrighamChiefs #DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... BrighamChiefs #DILI ... #DrugInduced #Liver
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... (>1000): • DILI ... (Drug-induced liver ... Hepatopathy (shock liver ... LouLectures #Liver
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... of underlying liver ... disease, liver ... support, or liver ... Injury (DILI)
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... • Iatrogenic: DILI
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Causes of Acute Liver ... • Iatrogenic: DILI ... Unconjugated Bili ... > 90% of Total Bili
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
The Liver Consult ... GTT, indirect bili ... MELD - Chronic liver ... disease work up - Liver ... US - Prior liver
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Identify Acute Liver ... - Specific to liver ... Unconjugated Bili ... > 90% of Total Bili
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