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Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... or symptoms of liver ... Drug #induced #Liver ... differential #Diagnosis #Management ... gastroenterology #algorithm
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis Algorithm ... DILI suspicion ... injury, Previous DILI ... Injury #Diagnosis #Algorithm
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... and Type of Liver ... Pharmacology #Causes #DILI
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 Drug-Induced Liver Injury - Pathophysiology Indirect Idiosyncratic Direct BWH Medicine Chiefs @BrighamChiefs #DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... BrighamChiefs #DILI ... #DrugInduced #Liver
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... disease, liver ... Injury (DILI) ... Hepatitis Procedures Management ... gastroenterology #management
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... • Iatrogenic: DILI ... Unconjugated Bili ... > 90% of Total Bili ... differential #diagnosis #algorithm
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... (>1000): • DILI ... (Drug-induced liver ... Hepatopathy (shock liver ... LouLectures #Liver
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
The Liver Consult ... Focus on prior Liver ... GTT, indirect bili ... MELD - Chronic liver ... US - Prior liver
Hepatocellular Carcinoma (HCC) in Cirrhosis - Management Algorithm Very early (0) - Single <2 cm, Preserved liver
in Cirrhosis - Management ... Algorithm Very ... cm, Preserved liver ... HCC #Cirrhosis #Management ... #Algorithm #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... 10x ULN), ↑Tbili/Dbili ... Intrahepatic Cholestasis Management ... obgyn #diagnosis #management
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