9 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... #DOAC #Bridging ... Anticoagulant #Anticoagulation ... #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Anticoagulants Common ... PCC (Kcentra) - Heparin ... (Praxbind) - Apixaban ... #doac #noac #pharmacology ... #hematology #reversal
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Anticoagulant Agents ... , 0% Renal Apixaban ... 80% Renal Edoxaban ... 35% Renal #DOAC ... #NOAC #Metabolism
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants ... : A new oral anticoagulant ... #LMWH #UFH #DOAC ... #Dabigatran #Apixaban ... #NOAC #Mechanism
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... procedure Stop anticoagulant ... , Edoxaban or Rivaroxaban ... #Reversal #NOAC ... #Oral #anticoagulant
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
and rivaroxaban ... anticoagulants ... filtration rate; DOAC ... anticoagulant; ... #DOAC #VTE #Malignancy
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
Effect of Direct Oral ... Anticoagulants ... , rixaroxaban, apixaban ... thrombin time #doac ... #noac #anticoagulation
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
consider withholding anticoagulant ... decision to continue anticoagulant ... DOAC, direct oral ... anticoagulant; ... #DOAC #VTE #Malignancy
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
#models #hematology ... #anticoagulant ... #Warfarin #Dabigatran ... #Rivaroxaban #Edoxaban ... #heparin #pathway