13 results
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
NOAC / DOAC Pharmacology ... Novel (or Direct) Oral ... • Apixaban • Dabigatran ... #NOAC #DOAC #Pharmacology ... management #Direct #Oral
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
of Clearance of Oral ... Hepatic, 25% Renal Dabigatran ... Hepatic, 35% Renal #DOAC ... #NOAC #Metabolism ... Pharmacology #Clearance #oral
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... Clotmaster #VTE #DOAC ... Bridging #Dosing #Oral ... Anticoagulation #Dabigatran
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
stratification algorithm ... direct-acting oral ... direct-acting oral ... #Cancer #Algorithm ... Management #Hematology #Oncology
Oral Anticoagulation Management Cheat Sheet: Warfarin, Apixaban, Dabigatran, Rivaroxaban
 - Mechanism of Action
 - Routine Blood
Oral Anticoagulation ... Warfarin, Apixaban, Dabigatran ... - Resume #Oral ... Anticoagulant #DOAC
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... DOACs are substrates ... metabolization of DOACs ... Dabigatran has moderate ... #Chemotherapy #Oncology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Fondaparinux, and Novel Oral ... subcutaneous) and oral ... Heparins #LMWH #UFH #DOAC ... #Dabigatran #Apixaban ... #Fondaparinux #NOAC
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... direct acting oral ... anticoagulants (DOACs ... of Therapy • Dabigatran ... postoperative #DOAC
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... modified factor Xa • Dabigatran ... not available #DOAC ... #Reversal #NOAC ... #Oral #anticoagulant
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
Treatment algorithm ... Suggested treatment algorithm ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Management #Hematology #Oncology