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differential transaminitis aflp ascites causes chemistry fatty function gap globulin gradient hematology hypertension injury interpretation management obgyn obstetrics pathophysiology patterns
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... Hepatopathy • Acute ... Viral Hepatitis ... Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 20x normal - Acute ... #Injury #hepatology ... #LFTs #transaminitis ... #differential # ... diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Production: • Albumin ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
Diagnosis High ... - Alcoholic hepatitis ... Veno-occlusive disease - Acute ... fatty liver of ... #Diagnosis #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... AP, ↑INR, ↑BUN/Cr ... infiltration) Differential ... Hepatitis, Preeclampsia ... #Pregnancy #hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Diagnosis Portal ... INR, bilirubin, albumin ... • Cirrhosis/acute ... hepatitis • Infiltrative ... #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Total Protein - Albumin ... concentration minus albumin ... Sarcoidosis) • Liver ... Gap #ProteinGap #differential ... #diagnosis #hematology
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