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differential aflp algorithm causes injury lfts obstetrics pregnancy saag transaminitis albumin chemistry comparison disease druginduced function gradient hellp hypertension icp
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... develops (DIC, ascites ... infiltration) Differential ... Hepatitis, Preeclampsia ... #hepatology #obstetrics
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Diagnosis Framework ... Hepatopathy • Acute ... Viral Hepatitis ... (>1000): • DILI ... #Diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... dechallenge • Acute ... disorder (e.g. ascites ... ), Chronic hepatitis ... #hepatology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
fibrosis - Acute ... fatty liver of ... #Causes #diagnosis ... #differential # ... hepatology #SAAG
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... • Iatrogenic: DILI ... #hepatology
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
Diagnosis High ... - Alcoholic hepatitis ... Veno-occlusive disease - Acute ... fatty liver of ... #Diagnosis #hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Diagnosis Portal ... • Cirrhosis/acute ... hepatitis • Infiltrative ... metastasis • Fatty ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... viral hepatitis ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
and hemorrhage Acute ... Fatty Liver of ... #obstetrics #hepatitis ... #comparison #differential ... #diagnosis #icp
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