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diagnosis betadglucan galactomannan infectiousdiseases laboratory management aspergillus invasive treatment antibiotic antifungal auris biomarkers candida candidiasis characteristics comparison falsepositives fungi fungus
1,3 Beta-D-Glucan and Galactomannan - Pathogens, and Testing Characteristics 1,3 ß-D-glucan: • Most fungi excluding mucor and
Pathogens, and Testing ... ß-D-glucan: • Most fungi ... Galactomannan #Pathogens #Testing ... Characteristics #Sensitivity ... #Fungi #Fungal
Invasive Candidiasis (IC) Diagnosis: Culture: • Gold standard, but Slow (~2-3 days), 50% sensitivity • Blood Sample •
2-3 days), 50% sensitivity ... Conduct antifungal susceptibility ... testing (AFST)
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... dermatidis • Sensitivity ... : Mucorales • Sensitivity ... disease - Sensitivity ... Frozen ice-pops (in setting
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Galactomannan Testing ... Sensitivity Specificity ... component of many fungi ... closely related fungi ... #Testing #FalsePositives
Antibiotic Susceptibility Testing Methods 1) Kirby Bauer Disk Diffusion: disks impregnanted w/ Abx → circular gradient →
Antibiotic Susceptibility ... Testing Methods ... #Antibiotic #Sensitivity ... #Susceptibility ... #Testing #laboratory
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
Diagnosis and Testing ... Galactomannan sensitivity ... associated with low sensitivity ... Management #treatment #fungal
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
antigen assay has a sensitivity ... Diagnosis: • Direct fungal ... Urinary antigen testing ... arthroconidia; the fungus ... InfectiousDiseases #Fungal
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