13 results
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
vomiting • Fatigue Signs ... Cortisol Deficiency: Signs ... Reduced libido • Signs ... #disease #endocrinology ... #diagnosis #signs
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... tissue expansion (e.g ... #FeedbackLoop #endocrinology ... #pathophysiology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
risk factors (eg ... hypertension (eg ... hypertension and signs ... hypertension (eg ... renal bruit or signs
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... unless worrisome EKG
Intraoperative Cardiac Ischaemia - Guidelines for Crises in Anaesthesia

If the patient is unconscious, signs of cardiac
is unconscious, signs ... is conscious, symptoms ... trolley and 12-lead ECG ... CM5 continuous ECG ... Obtain a 12-lead ECG
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
Signs of immunodeficiency ... humoral immunity Signs ... /Symptoms/Findings ... bacterial infections (e.g ... Agammaglobulinemia #XLinked #pathophysiology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
those coming off aorta ... systemic sx + signs ... not be subtle e.g ... E.g. 80 yo ESR cutoff ... GCA #Temporal #Signs
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... patients have no symptoms ... of diagnosis (e.g ... Diagnosis #Management #Signs ... #Symptoms
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
- Causes progressive ... of UMN and LMN signs ... of UMN and LMN signs ... both UMN and LMN signs ... EMG: LMN Signs in
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features
1) Skin
 • Thin, easily bruisable skin with
exposed tothe sun (e.g ... , oral cavity) Caused ... gluconeogenesis enzymes (e.g ... Hypercortisolism #Diagnosis #signs ... #symptoms #endocrinology