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diagnosis hematology causes algorithm hemolytic oncology signs extravascular hemolysis management agglutinin chronic classification clues cold crisis deficiency disease eosinophil eosinophilia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... lymphoproliferative disorders ... Intrinsic RBC Defects ... #Causes #differential ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... • Sickle cell ... immune-complex hemolytic anemia ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
of anemia include ... younger pts) Differential ... the RBCs causing intravascular ... : High fevers, chills ... #hematology #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider sickle cell ... Consider RBC membrane disorder ... Diagnosis #Algorithm #workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... lymphoproliferative disorders ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... evaluation or workup ... organ-specific signs ... #Algorithm #Differential ... #diagnosis #hematology
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
- Coagulation disorder ... , neural tube defects ... Vitamins #Deficiency #differential ... #diagnosis #signs ... #symptoms #nutrition
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... Diagnosis and Workup ... pylori test (GI symptoms ... changes), high MCV anemia ... #hematology
Signs and Symptoms Associated With Different Headache Etiologies • Nonfocal mental status changes - Meningitis, encephalitis,
Signs and Symptoms ... , anemia, febrile ... (CN Ill, IV, and ... #symptoms #clues ... #differential #
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
recessive blood disorder ... almost exclusively affects ... of the baseline anaemia ... Crisis #Features #Signs ... #Symptoms
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