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diagnosis hematology hemolytic algorithm causes extravascular hemolysis oncology agglutinin chronic cll cold disease leukemia lymphocytic mds myelodysplasia myelodysplastic nutrition signs
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... • G6PD deficiency ... • PK deficiency ... immune-complex hemolytic anemia ... #Differential #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Intrinsic RBC Defects ... G6PD deficiency) ... #Causes #differential ... #diagnosis #hematology ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... #Differential # ... Diagnosis #Algorithm #workup ... #hematology #testing
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... , neural tube defects ... #differential # ... diagnosis #signs ... #symptoms #nutrition
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
of anemia include ... younger pts) Differential ... the RBCs causing intravascular ... : High fevers, chills ... #hematology #diagnosis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
low, tests to detect ... reflection of intravascular ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• M > F • Affects ... with no early symptoms ... Physical Exam/Signs ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... or folic acid deficiency ... Workup: • Complete ... blood count with differential
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