12 results
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
Motor and sensory deficits ... pain • Extra-CNS ... , Comorbid autoimmune ... Manifestations #diagnosis #neurology ... #symptoms #signs
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... Lack of UMN/LMN signs ... necrotizing myopathy • Autoimmune ... #Weakness #Differential ... #Diagnosis #neurology
Approach to Headaches - Differential Diagnosis Algorithm

Red flags (PHANTOMS):
 • Pattern change, progressively worse, papilledema
 •
to Headaches - Differential ... • Neurological deficits ... ) • Systemic symptoms ... brain lesion • CNS ... Diagnosis #Algorithm #neurology
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
heliotrope, shawl sign ... exclusion Necrotizing Autoimmune ... Inflammatory #Myopathies #differential ... diagnosis #comparison #rheumatology ... #table
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Sclerosis (MS) is an autoimmune-mediated ... neuritis • Partial myelitis ... Afferent pupillary defect ... SIGNS/SYMPTOMS ... Signs and symptoms
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... • Bilateral signs ... and/or symptoms ... diagnosis #management #neurology ... #differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Agglutinin Syndrome (CAS ... Viral infection, autoimmune ... CLL (older) • Autoimmune ... younger pts) Differential ... : High fevers, chills
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
technique used to detect ... context of other symptoms ... Sjögren Syndrome, Myositis ... ANA #patterns #rheumatology ... #diagnosis #differential
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
skin injury) • Neurologic ... symptoms (headache ... Behcet disease) Differential ... diagnosis #management #signs ... #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... rheumatologic diseases ... and CNS • Headache ... • Transverse Myelitis ... Induced Lupus: • Symptoms