18 results
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... deficiency: ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... GH excess prior ... Overproduction #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Phosphate Physical Symptoms ... : Commonly no signs ... pain Psychiatric Symptoms ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
vomiting • Fatigue Signs ... : Signs • Hyperpigmentation ... Reduced libido • Signs ... addisons #disease #endocrinology ... #diagnosis #signs
Congenital Adrenal Hyperplasia - 21-Hydroxylase Deficiency - Signs and Symptoms
 • Brain: Androgenization effects, Glucocorticoid effects,
21-Hydroxylase Deficiency ... - Signs and Symptoms ... #Hydroxylase #Deficiency ... #Signs #Symptoms ... #diagnosis #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... Signs/Symptoms: ... Pretibial myxedema #Primary ... Hyperthyroidism #endocrinology ... #pathophysiology
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
hypothyroidism Pathophysiology ... : • T4 deficiency ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Circulating galactose-deficient ... Deficiency in galactosylation ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... following order; GH ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Atrioventricular defects ... Subacute development, primarily ... PM #Diagnosis #Pathophysiology ... #Signs #Symptoms ... #Vasculitis