17 results
Immune Checkpoint Inhibitor Toxicity

Main Toxicities: Colitis,  
Pneumonitis, Skin adverse events, Endocrine dysfunction, 
Hepatitis,  
Myocarditis,
Checkpoint Inhibitor Toxicity ... Incidence, Symptoms ... Complications and Treatment ... Table #Diagnosis #Pharmacology ... #Oncology
Post-Intensive Care Syndrome (PICS)
Symptoms of PICS:
 - Physical Domain: Generalized weakness, Fatigue, Difficulty walking
 - Cognitive
Syndrome (PICS) Symptoms ... analgesics - Delirium ... guide targeted treatments ... - Delirium ... diagnosis #management #criticalcare
Checklist for Treatment of Delirium in the ICU 

Remove causative factors 
 - 
Exclude hypoglycemia if
Checklist for Treatment ... of Delirium in ... sleeping, administer pharmacologic ... #Delirium #Checklist ... #MICU #CriticalCare
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Splenomegaly 5) Symptoms ... transformation) Treatment ... Constitutional symptoms ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Pain, Agitation, and Delirium (PAD) in the ICU
Addressing the ICU Triad (PAD) can be accomplished through
Agitation, and Delirium ... glycol (solvent) toxicity ... No pharmacologic ... (Haldol) - No pharmacologic ... #PAD #ICU #CriticalCare
Testicular Cancer - Treatment Related Toxicities

Bleomycin, Cisplatin, Etoposide, lfosfamide
Tinnitus & Hearing Loss
Neurotoxicity
Pulmonary Fibrosis
Hypotension
Nephrotoxicity
Skin Hyperpigmentation
Hemorrhagic Cystitis
Myelosuppression
Peripheral Neuropathy

Ashley
Testicular Cancer - Treatment ... #chemotherapy #toxicity ... toxicology #Toxicities #pharmacology ... #oncology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Diagnosis: >3 symptoms ... Renal Failure Treatment ... diagnosis #management #hematology ... #oncology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
patients who have treatment-resistant ... effect on negative symptoms ... #Toxicology #Toxicity ... #Diagnosis #Pharmacology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology