6 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Diagnosis Framework ... /Quantity: • Primary ... : ITP • Secondary ... - Hemolytic anemia ... #nonpalpable #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... intravascular coagulation (DIC ... thrombocytopenic purpura ... usually IgM) (e.g. primary ... #hematology #anemia
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Abnormalities in primary ... or secondary hemostasis ... fulminans - DIC ... #dermatology #physicalexam
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Petechiae • Purpura ... Treatment: • Treat primary ... cause • Correct ... #Coagulation #diagnosis ... #management #hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Primary (essential ... Skin necrosis • Purpura ... Cryofibrinogenemia Diagnosis ... cryoglobulins • Negative causes ... skin necrosis • DIC
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP Score ... - infiltrates (anemia ... + distinctive primary ... Fibrinolysis & DIC ... #Oncology #Diagnosis