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Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
- Ventricular Depolarization ... Action, ↑ EFR & AP ... Action, ↓ EFR & AP ... Action, ←→ EFR & AP ... phase 2 (↑ERP & ↑AP
Action potential in cardiomyocytes The action potential in typical cardiomyocytes is composed of 5 phases (0-4), beginning
phase Phase 0: Depolarization ... Phase 1: Early repolarization ... phase Phase 3: Repolarization ... Myocytes #Phases #Depolarization ... #Repolarization
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
and magnitude of depolarization ... Action, ↑ EFR & AP ... Action, ↓ EFR & AP ... Action, ←→ EFR & AP ... phase 4 to slow depolarization
Differential Diagnosis for ST Segment Elevations - ACUTE STEMI - PULMONARY EMBOLISM - LBBB
EMBOLISM - LBBB (PACEMAKER ... - BENIGN EARLY REPOLARIZATION
WAP - Wandering Atrial Pacemaker #Clinical #Cardiology #MedStudent #EKG #WAP #WanderingAtrialPacemaker #ECGEducator
WAP - Wandering ... Atrial Pacemaker ... MedStudent #EKG #WAP
Temporary / External Pacing • Transvenous & epicardial pacing are temporary methods of supporting brady- &
permanent implanted pacemaker ... required to trigger depolarization ... to identify a depolarization ... MD @nickmmark #pacemaker
CAP, HCAP, HAP and VAP - Diagnosis and Treatment HCAP & CAP – those presenting to the
CAP, HCAP, HAP and ... VAP - Diagnosis ... with pneumonia HAP ... & VAP – those that ... #HCAP #HAP #VAP
Comparison between Wandering atrial pacemaker (A) vs multifocal atrial arrhythmia (B) #WAP #MAR #wandering #atrial #pacemaker #comparison
Wandering atrial pacemaker ... arrhythmia (B) #WAP ... wandering #atrial #pacemaker
Pacemaker Operating Modes 1 - Chamber paced A (atrium), V (ventricle), D (dual/both) 2
Pacemaker Operating ... or paced atrial depolarization ... after ventricular depolarization ... to an intrinsic depolarization ... order to initiate depolarization
Antiarrhythmics - Vaughan Williams Classification Class I (Ia, Ib, Ic) - Na+ Channel Blockade • Slows depolarization
Blockade • Slows depolarization ... in fast AP cells ... Blockade • Slows depolarization ... in slow AP cells ... Blockade • Slows depolarization
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