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Action potential in cardiomyocytes The action potential in typical cardiomyocytes is composed of 5 phases (0-4), beginning
phase Phase 0: Depolarization ... Phase 1: Early repolarization ... phase Phase 3: Repolarization ... Myocytes #Phases #Depolarization ... #Repolarization
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
- Ventricular Depolarization ... • Atrial depolarization ... and magnitude of depolarization ... phase 4 to slow depolarization ... Classification #Classes
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
and magnitude of depolarization ... phase 4 to slow depolarization ... prolong AV node repolarization ... prolong AV node repolarization ... Classification #Classes
Pacemaker Operating Modes 1 - Chamber paced A (atrium), V (ventricle), D (dual/both) 2
or paced atrial depolarization ... after ventricular depolarization ... to an intrinsic depolarization ... order to initiate depolarization ... #Pacemaker #PPM
Action Potential: Depolarization and repolarization of a neuron #ActionPotential #Depolarization #Repolarization #Neuron #Neurology #Pathophysiology
Action Potential: Depolarization ... and repolarization ... ActionPotential #Depolarization ... #Repolarization
Class I Antiarrhythmics and their Key Pharmacologic Properties Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer") Class IB
for the rapid depolarization ... • Slows depolarization ... involved in phase 3 repolarization ... • Prolongs repolarization
Major electrocardiogram findings induced by left ventricular hypertrophy (LVH) An increase in left ventricular mass augments the
alteration in repolarization ... in left atrial depolarization
Antiarrhythmics - Vaughan Williams Classification Class I (Ia, Ib, Ic) - Na+ Channel Blockade • Slows depolarization
Blockade • Slows depolarization ... Blockade • Slows depolarization ... Blockade • Slows depolarization ... Classification #Classes
Temporary / External Pacing • Transvenous & epicardial pacing are temporary methods of supporting brady- &
required to trigger depolarization ... to identify a depolarization ... nickmmark #pacemaker #PPM
Hyperkalemia shortens repolarization; changes in the T wave provide the earliest clues to hyperpotassemia. - At
Hyperkalemia shortens repolarization ... provide the earliest clues ... 6.0 mEq/L, rapid repolarization ... causes peaked T ... in conduction causes
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