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Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
- Ventricular Depolarization ... • Atrial depolarization ... phase 4 to slow depolarization ... interval (delays time repolarization ... prolong AV node repolarization
Class I Antiarrhythmics and their Key Pharmacologic Properties Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer") Class IB
Class I Antiarrhythmics ... for the rapid depolarization ... • Slows depolarization ... involved in phase 3 repolarization ... • Prolongs repolarization
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
and magnitude of depolarization ... phase 4 to slow depolarization ... prolong AV node repolarization ... interval (delays time repolarization ... prolong AV node repolarization
Action potential in cardiomyocytes The action potential in typical cardiomyocytes is composed of 5 phases (0-4), beginning
phase Phase 0: Depolarization ... Phase 1: Early repolarization ... phase Phase 3: Repolarization ... Myocytes #Phases #Depolarization ... #Repolarization
Action Potential: Depolarization and repolarization of a neuron #ActionPotential #Depolarization #Repolarization #Neuron #Neurology #Pathophysiology
Action Potential: Depolarization ... and repolarization ... ActionPotential #Depolarization ... #Repolarization
Antiarrhythmics - Vaughan Williams Classification Class I (Ia, Ib, Ic) - Na+ Channel Blockade • Slows depolarization
Classification Class ... Blockade • Slows depolarization ... Widens QRS complex Class ... Blockade • Slows depolarization ... Blockade • Slows depolarization
Major electrocardiogram findings induced by left ventricular hypertrophy (LVH) An increase in left ventricular mass augments the
alteration in repolarization ... in left atrial depolarization
Distinguishing Between Benign Early repolarization vs STEMI on EKG #Diagnosis #Cardiology #ECG #EKG #Repolarization #STEMI #Comparison #Table
Between Benign Early repolarization ... Cardiology #ECG #EKG #Repolarization
Hyperkalemia shortens repolarization; changes in the T wave provide the earliest clues to hyperpotassemia. - At
Hyperkalemia shortens repolarization ... 6.0 mEq/L, rapid repolarization ... causes peaked T ... in conduction causes ... wave to produce classic
ECG characteristics of early repolarization - The ST segment elevations are concave and most pronounced in
characteristics of early repolarization ... hallmark of early repolarization ... EKG #ECG #Early #Repolarization
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