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Action potential in cardiomyocytes The action potential in typical cardiomyocytes is composed of 5 phases (0-4), beginning
phase Phase 0: Depolarization ... Phase 1: Early repolarization ... phase Phase 3: Repolarization ... Myocytes #Phases #Depolarization ... #Repolarization
Action Potential: Depolarization and repolarization of a neuron #ActionPotential #Depolarization #Repolarization #Neuron #Neurology #Pathophysiology
Action Potential: Depolarization ... and repolarization ... ActionPotential #Depolarization ... #Repolarization
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
- Ventricular Depolarization ... Delays ventricular repolarization ... and magnitude of depolarization ... prolong AV node repolarization ... prolong AV node repolarization
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
and magnitude of depolarization ... phase 4 to slow depolarization ... prolong AV node repolarization ... interval (delays time repolarization ... prolong AV node repolarization
Class I Antiarrhythmics and their Key Pharmacologic Properties Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer") Class IB
for the rapid depolarization ... • Slows depolarization ... involved in phase 3 repolarization ... • Prolongs repolarization
Temporary / External Pacing • Transvenous & epicardial pacing are temporary methods of supporting brady- &
Temporary / External Pacing ... Transvenous & epicardial pacing ... External cardiac pacing ... required to trigger depolarization ... to identify a depolarization
Major electrocardiogram findings induced by left ventricular hypertrophy (LVH) An increase in left ventricular mass augments the
alteration in repolarization ... in left atrial depolarization
Distinguishing Between Benign Early repolarization vs STEMI on EKG #Diagnosis #Cardiology #ECG #EKG #Repolarization #STEMI #Comparison #Table
Between Benign Early repolarization ... Cardiology #ECG #EKG #Repolarization
Antiarrhythmics - Vaughan Williams Classification Class I (Ia, Ib, Ic) - Na+ Channel Blockade • Slows depolarization
Blockade • Slows depolarization ... Blockade • Slows depolarization ... Blockade • Slows depolarization
Pacemaker Operating Modes 1 - Chamber paced A (atrium), V (ventricle), D (dual/both) 2
or paced atrial depolarization ... before pacing the ... after ventricular depolarization ... to an intrinsic depolarization ... order to initiate depolarization
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