12 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Endocarditis, Idiopathic ... Glomerulonephritis #Vasculitis ... #differential # ... diagnosis #algorithm ... #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... Pigmented Purpuric Dermatosis ... - GPA - EGPA ... #Diagnosis #hematology ... #rheumatology #
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated Vasculitis ... pathologically or clinically ... #differential # ... diagnosis #algorithm ... #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... reticularis Differential ... Diagnosis: Vasculitis ... disease • Non-Hodgkin ... #diagnosis #rheumatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Lymphoma - Clinical ... Weight loss • Anemia ... Immunohistochemical studies (to differentiate ... #classification ... #hematology #oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... > PR3 60% • GPA ... differential #diagnosis ... #rheumatology # ... classification
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... Cryoglobulinemia Syndrome • Idiopathic ... - GPA, EGPA, microscopic ... #types #classification ... #rheumatology #
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... vasculopathy Idiopathic ... Chronic hemolytic anemia ... neurofibromatosis, vasculitis ... #Diagnosis #Differential
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Neutrophilic dermatosis ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Disease (CAD): - Idiopathic ... Viral Infection Clinical ... younger pts) Differential ... #hematology #diagnosis