8 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... ANCA (C-ANCA): GPA ... , MPA >>> GPA Stanford ... #differential # ... #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Pigmented Purpuric Dermatosis ... - GPA - EGPA ... #Diagnosis #hematology ... #rheumatology #
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
pathologically or clinically ... polyangiitis (GPA ... #differential # ... diagnosis #algorithm ... #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA ... polyangiitis (GPA ... GPA causes disease ... #Polyangiitis #GPA ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
> PR3 60% • GPA ... and branches • GCA ... • ANCA (Dx: GPA ... #rheumatology # ... classification
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Syndrome: • Clinical ... - GPA, EGPA, microscopic ... diagnosis #types #classification ... #rheumatology #
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
cell arteritis (GCA ... cell arteritis (GCA ... Diagnosis = clinical ... very remarkable w/differential ... them, but urgent rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Elevated ESR and CRP GCA ... develop in pts with GCA ... MPO > PR3 60/ GPA ... Diagnosis #Rheumatology