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diagnosis anemia causes large medium vesselsize algorithm cold dermatology disease erythematosus hemolysis intravascular lupus monoclonal nonpalpable oncology palpable paraproteinemias purpura
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
. primary cold agglutin ... #Hemolytic #Intravascular ... #Extravascular ... #Causes #differential ... #diagnosis #hematology
Break down Vasculitis based on vessel size #Diagnosis #Rheumatology #Differential #Vasculitis #VesselSize #Small #Medium #Large #Classification
Break down Vasculitis ... size #Diagnosis #Rheumatology ... #Differential # ... #Small #Medium ... #Large #Classification
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... younger pts) Differential ... the RBCs causing intravascular ... #disease #hemolytic ... #anemia #hematology
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
, and small vessel ... Small vessel vasculitis ... #Diagnosis #Rheumatology ... #Differential # ... #Large #Classification
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Agglutination - Cold agglutinins ... cardiac valve, vasculitis ... #Anemia #Differential ... Algorithm #workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... Pigmented Purpuric Dermatosis ... ANCA associated small ... #Diagnosis #hematology ... #rheumatology #
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... IVIG infusion Intravascular ... Diagnosis #causes #classification ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... abnormalities SMALL ... pain, infarct • Small ... #rheumatology # ... classification
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Neutrophilic dermatosis ... • Coombs (-) hemolytic ... Subcorneal pustular dermatosis ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... and infarcts SMALL ... - interstitial keratitis ... Diagnosis #Rheumatology
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